- Central Mississippi Planning and Development District - Regional planning organization serving the governments of Copiah, Hinds, Madison, Rankin, Simpson, Warren and Yazoo counties. Information about planning, economic development, workforce training, agency on aging, and other programs.
- Golden Triangle Planning and Development District - Regional agency serving local governments in Choctaw, Clay, Lowndes, Noxubee, Oktibbeha, Webster, and Winston counties with economic development, E-911, childcare, senior services, and related functions.
- Mid-Mississippi Development District - Providing information on available buildings and sites for industrial expansion and relocation.
- North Mississippi Industrial Development Association - Organization of electrical power distributors serving most of northern and northeastern Mississippi, organized to generate business and industry prospects. Information about the region, community resources, and available sites and incentives.
- Northeast Mississippi Planning and Development District - Serves county and municipal governments in Alcorn, Benton, Marshall, Prentiss, Tippah, and Tishomingo counties by providing technical assistance and information.
- Region 8 Mental Health Services - Provider of services for people with developmental disabilities and treatment and prevention for mental and emotional problems in Rankin, Madison, Simpson, and Copiah Counties.
- Sacred Heart League - Roman Catholic organization serving the nine northern counties of Mississippi in parish, education, housing and social ministries.
- Southern Mississippi Planning and Development District - Regional planning entity assisting 15 county and 37 municipal governments in Covington, Forrest, George, Greene, Hancock, Harrison, Jackson, Jefferson Davis, Jones, Lamar, Marion, Pearl River, Perry, Stone and Wayne Counties.
- Sunshine Shelter Abused Children Shelter - An emergency shelter for abused and neglected children in MS Department of Human Services Region V, covering 13 counties.
- Three Rivers Planning and Development District - Non-profit regional intergovernmental organization that serves Calhoun, Chickasaw, Itawamba, Lafayette, Lee, Monroe, Pontotoc, and Union counties in economic development, solid waste management, health and aging, and related services.
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